Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Cdh1tm2Kem
Name:	cadherin 1; targeted mutation 2, Rolf Kemler
MGI ID:	MGI:2389020
Synonyms:	Ecadfl, E-cadherinflox, E-cadherinfloxed, E-cadlox
Gene:	Cdh1  Location: Chr8:107329983-107396878 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Alliance:	Cdh1tm2Kem page

Germline Transmission:	Earliest citation of germline transmission: J:77170
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: Single loxP sites flanked a region encompassing exons 6 through 10 followed by a floxed selection cassette was excised via in vitro cre mediated recombination. (J:77170)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdh1tm2Kem

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:	171 strains or lines available

Original:	J:77170 Boussadia O, et al., E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002 Jul;115(1-2):53-62
All:	75 reference(s)