Tg(Hoxb7-RET-M918T)1Vpa
Transgene Detail
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| Symbol: |
Tg(Hoxb7-RET-M918T)1Vpa |
| Name: |
transgene insertion 1, Vassilis Pachnis |
| MGI ID: |
MGI:2388560 |
| Synonyms: |
Hoxb7-Ret9-MEN2B |
| Transgene: |
Tg(Hoxb7-RET-M918T)1Vpa Location: unknown
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| Alliance: |
Tg(Hoxb7-RET-M918T)1Vpa page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Hoxb7-RET-M918T)1Vpa expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
RET (5979) |
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Transgene codes for a protein with a methionine to threonine mutation. |
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Mutation details: The transgene consists of a human RET cDNA encoding the RET9 isoform with a methionine to threonine substitution at position 918 (M918T) fused to mouse Hoxb7 promoter sequences (-1316 to +81). Mouse Hoxb7 promoter was used to drive expression of the transgene throughout the uretic bud branches. The M918T mutation is associated with the human disease MEN2Bsyndrome.
(J:71588)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Trangenic founder mice were sacrificed at day E18.5 for analysis.
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| Original: |
J:71588 de Graaff E, et al., Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev. 2001 Sep 15;15(18):2433-44 |
| All: |
1 reference(s) |
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Analysis Tools
