Tg(Eno2-Casp1-C285G)1Yuan
Transgene Detail
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| Symbol: |
Tg(Eno2-Casp1-C285G)1Yuan |
| Name: |
transgene insertion 1, Junying Yuan |
| MGI ID: |
MGI:2385754 |
| Synonyms: |
ICEC285G |
| Transgene: |
Tg(Eno2-Casp1-C285G)1Yuan Location: unknown
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| Alliance: |
Tg(Eno2-Casp1-C285G)1Yuan page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene is comprised of a dominant negative mutant Casp1 gene carrying a cysteine to glycine substitution at position 285 (C285G) fused to lacZ and the enolase 2 promoter. The enolase 2 promoter was used to direct expression of the transgene to cells of the nervous system. Transgenic animals were identified by PCR genotyping. X-gal staining of transgenic tissues detected transgene expression in the dorsal root ganglion.
(J:38779)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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This allele is representative of 5 different founders carrying the highest number of transgene integrations. These are founders 7506, 7512, 7516, 7538, and 7539.
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| Original: |
J:38779 Friedlander RM, et al., Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med. 1997 Mar 3;185(5):933-40 |
| All: |
4 reference(s) |
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Analysis Tools
