Tg(Hoxb7-RET/AKAP1)1Cos
Transgene Detail
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| Symbol: |
Tg(Hoxb7-RET/AKAP1)1Cos |
| Name: |
transgene insertion 1, Frank Costantini |
| MGI ID: |
MGI:2388558 |
| Synonyms: |
Hoxb7/RET9-PTC2, Hoxb7/RET-PTC2 |
| Transgene: |
Tg(Hoxb7-RET/AKAP1)1Cos Location: unknown
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| Alliance: |
Tg(Hoxb7-RET/AKAP1)1Cos page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Hoxb7-RET/AKAP1)1Cos expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
AKAP1 (8165) |
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Transgene codes for a fusion protein of RET and AKAP1. |
| human |
RET (5979) |
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Transgene codes for a fusion protein of RET and AKAP1. |
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Mutation details: The transgene consists of the tyrosine kinase domain of human RET fused to a portion of the human AKAP1 gene, followed by sequences from human beta globin. The fusion gene is found in certain papillary thyroid carcinomas as a result of chromosomal rearrangement. Mouse Hoxb7 promoter sequences drive transgene expression throughout the uretic bud branches.
(J:52988)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Trangenic founders all exhibit low transgene copy numbers and a low frequency of transmission to progeny. Four out of seven transgenic embryos examined at days E19-E19 displayed renal abnormalities.
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| Original: |
J:52988 Srinivas S, et al., Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development. Development. 1999 Apr;126(7):1375-86 |
| All: |
1 reference(s) |
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Analysis Tools
