Tg(CD4-HIV)2Pjo
Transgene Detail
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| Symbol: |
Tg(CD4-HIV)2Pjo |
| Name: |
transgene insertion 2, Paul Jolicoeur |
| MGI ID: |
MGI:2388570 |
| Synonyms: |
CD4A/HIVWT |
| Transgene: |
Tg(CD4-HIV)2Pjo Location: unknown
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| Alliance: |
Tg(CD4-HIV)2Pjo page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The human CD4 promoter, 8.8 kb of HIV sequences, and an SV40 polyadenylation signal was used for the transgene. The promoter sequences were used to drive expression in CD4+ T cells and cells of the dendritic/macrophage lineage. Northern blot analysis showed barely detectable transgene expression in the thymus and spleen of transgenic animals.
(J:78757)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Four transgenic founder lines were created and did not exhibit a phenotype. Transgenic animals remained healthy up to time of sacrifice, approximately 12 to 24 months.
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| Original: |
J:78757 Hanna Z, et al., Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease. J Virol. 1998 Jan;72(1):121-32 |
| All: |
2 reference(s) |
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Analysis Tools
