Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfsf4tm1Sug
Name:	tumor necrosis factor (ligand) superfamily, member 4; targeted mutation 1, Kazuo Sugamura
MGI ID:	MGI:2388724
Synonyms:	OX40-KO, OX40L-
Gene:	Tnfsf4  Location: Chr1:161223009-161245777 bp, + strand  Genetic Position: Chr1, 69.75 cM
Alliance:	Tnfsf4tm1Sug page

Germline Transmission:	Earliest citation of germline transmission: J:59412
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by FACS analysis of activated B cells obtained from homozygous mutant mice. (J:59412)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf4 Mutation:	31 strains or lines available

Original:	J:59412 Murata K, et al., Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med. 2000 Jan 17;191(2):365-74
All:	15 reference(s)