Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Abcc8tm1.1Mgn
Name:	ATP-binding cassette, sub-family C member 8; targeted mutation 1.1, Mark A Magnuson
MGI ID:	MGI:2388392
Synonyms:	SUR1-, Sur1neo
Gene:	Abcc8  Location: Chr7:45753952-45829441 bp, - strand  Genetic Position: Chr7, 29.66 cM
Alliance:	Abcc8tm1.1Mgn page

Germline Transmission:	Earliest citation of germline transmission: J:79352
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed region containing the promoter and exon 1 was excised via cre mediated recombination of Abcctm1Mgn. The neo cassette in intron 1 remained. (J:79352)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcc8 Mutation:	77 strains or lines available

Original:	J:79352 Shiota C, et al., Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem. 2002 Oct 4;277(40):37176-83
All:	17 reference(s)