Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gjd2tm1Kwi
Name:	gap junction protein, delta 2; targeted mutation 1, Klaus Willecke
MGI ID:	MGI:2388389
Synonyms:	Cx36 -
Gene:	Gjd2  Location: Chr2:113840082-113844100 bp, - strand  Genetic Position: Chr2, 57.54 cM, cytoband F3
Alliance:	Gjd2tm1Kwi page

Germline Transmission:	Earliest citation of germline transmission: J:70839
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding region of exon 2 and 170 bp of flanking noncoding sequences were replaced with a floxed HPRT minigene in the opposite orientation. RT-PCR analysis did not detect gene expression in the retina or brain of homozygous mutant animals. (J:70839, J:95216)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjd2 Mutation:	23 strains or lines available

Original:	J:70839 Guldenagel M, et al., Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36. J Neurosci. 2001 Aug 15;21(16):6036-44
All:	22 reference(s)