Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dab1tm2Cpr
Name:	disabled 1; targeted mutation 2, Jonathan A Cooper
MGI ID:	MGI:2388292
Synonyms:	Dab1-, dab1-5Fki
Gene:	Dab1  Location: Chr4:103476556-104602041 bp, + strand  Genetic Position: Chr4, 47.79 cM
Alliance:	Dab1tm2Cpr page

Germline Transmission:	Earliest citation of germline transmission: J:79475
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion, Nucleotide substitutions   Mutation details: To generate an allele lacking phosphorylation sites, the exon encoding amino acids 23 through 69 was replaced with a construct containing a splice acceptor and a modified partial cDNA encoding the p80 splice form. The cDNA was modified to encode phenylalanines in place of the 5 tyrosines residues (185, 198, 200, 220, 232) that are potential phosphorylation sites. Phosphorylation levels were undetectable by phosphopeptide analysis of protein produced by the targeted allele in vitro. (J:79475)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dab1 Mutation:	77 strains or lines available

Original:	J:79475 Howell BW, et al., Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. Curr Biol. 2000 Jul 27-Aug 10;10(15):877-85
All:	10 reference(s)