Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Tg(SOD1)3Cje
Name:	transgene insertion 3, Charles J Epstein
MGI ID:	MGI:2387864
Synonyms:	218/3, Cu/ZnSOD-Tg, CuZn SOD Tg, SOD1 TgHS/SF-213-3, SOD1 TGHS/SF-218-3, SOD TgN, SOD-TgN, TgHS-218/3, TgNSOD13Cje, TgN[SOD1]3Cje, hSOD1WT, tg-SOD
Transgene:	Tg(SOD1)3Cje  Location: unknown
Alliance:	Tg(SOD1)3Cje page

Strain of Origin:

(BALB/c x C57BL/6J)F1 x (C57BL/6J x DBA/2)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(SOD1)3Cje expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SOD1 (6647) Sod1  (MGI:98351)   Mutation details: The entire human SOD1 sequence was used for the transgene. Seven copies of the transgene inserted into Chromosome 3 (J:18645). Northern blot analysis of brain and liver from transgenic animals showed expression of 0.9 kb and 0.7 kb transcripts similar to that in humans. Transgenic animals exhibited increased enzyme activity in nearly all tissues examined. (J:30458)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:30458 Epstein CJ, et al., Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8044-8
All:	50 reference(s)