Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Top3btm1Jcw
Name:	topoisomerase (DNA) III beta; targeted mutation 1, James C Wang
MGI ID:	MGI:2388157
Synonyms:	top3beta-/-
Gene:	Top3b  Location: Chr16:16688600-16710854 bp, + strand  Genetic Position: Chr16, 10.46 cM, cytoband B1
Alliance:	Top3btm1Jcw page

Germline Transmission:	Earliest citation of germline transmission: J:69405
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A region of the gene spanning nucleotides 777 to 1490 of the coding sequence was replaced with a PGK-neo cassette. This region includes the active site tyrosine 336. Gene expression was undetectable by RT-PCR analysis of liver mRNA from homozygous mutant animals. (J:69405)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Top3b Mutation:	45 strains or lines available

Original:	J:69405 Kwan KY, et al., Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5717-21
All:	5 reference(s)