Ddr2tm1Kln
Targeted Allele Detail
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Symbol: |
Ddr2tm1Kln |
Name: |
discoidin domain receptor family, member 2; targeted mutation 1, Rudiger Klein |
MGI ID: |
MGI:2388155 |
Synonyms: |
DDR2- |
Gene: |
Ddr2 Location: Chr1:169799876-169938331 bp, - strand Genetic Position: Chr1, 76.84 cM, cytoband H1-H5
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Alliance: |
Ddr2tm1Kln page
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Skull comparison of Ddr1tm1Wfv/Ddr1tm1Wfv, Ddr2tm1Kln/Ddr2tm1Kln and Ddr2tm1Kln/Ddr2+ mice
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The exon encoding the ATP binding region of the kinase domain was replaced by a neo cassette inserted by homologous recombination. The absence of normal trancsript and normal protein was confirmed by Northern and Western blot analyses. In vitro studies showed normal proliferation of fibroblasts derived from homozygous mutant mice after infection with a retrovirus containing the wild-type cDNA.
(J:74580)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ddr2 Mutation: |
60 strains or lines available
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Original: |
J:74580 Labrador JP, et al., The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May;2(5):446-52 |
All: |
3 reference(s) |
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