Tg(Myh6-Tpm2)1Dfw
Transgene Detail
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| Symbol: |
Tg(Myh6-Tpm2)1Dfw |
| Name: |
transgene insertion 1, David F Wieczorek |
| MGI ID: |
MGI:2387933 |
| Synonyms: |
beta-TMstr, Tg(Myhca-Tpm2)1Dfw |
| Transgene: |
Tg(Myh6-Tpm2)1Dfw Location: unknown
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| Alliance: |
Tg(Myh6-Tpm2)1Dfw page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Myh6-Tpm2)1Dfw expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Tpm2 (MGI:98810) |
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Mutation details: The complete Tpm2 cDNA sequence and 3' untranslated region was used for the transgene. The transgene is expressed in adult heart tissue under the control of the Myhca promoter, which includes the 5' untranslated region and exons 1-3. Phosphoimaging analysis revealed a 150-fold and 34-fold increase in gene and protein expression, respectively, in hearts of transgenic animals.
(J:30336)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Nine different founders were constructed with transgene copy numbers varying from 4 to 56.
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| Original: |
J:30336 Muthuchamy M, et al., Molecular and physiological effects of overexpressing striated muscle beta-tropomyosin in the adult murine heart. J Biol Chem. 1995 Dec 22;270(51):30593-603 |
| All: |
7 reference(s) |
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Analysis Tools
