Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1btm1Hssh
Name:	calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Hee-Sup Shin
MGI ID:	MGI:2388140
Synonyms:	Cav2.2-
Gene:	Cacna1b  Location: Chr2:24493899-24653164 bp, - strand  Genetic Position: Chr2, 16.58 cM, cytoband A2
Alliance:	Cacna1btm1Hssh page

Germline Transmission:	Earliest citation of germline transmission: J:71480
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding a portion of the IS3 region was replaced with a cassette containing GFP and neo. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:71480)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1b Mutation:	103 strains or lines available

Original:	J:71480 Kim C, et al., Altered Nociceptive Response in Mice Deficient in the alpha(1B) Subunit of the Voltage-Dependent Calcium Channel. Mol Cell Neurosci. 2001 Aug;18(2):235-45
All:	6 reference(s)