Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stamtm1Sug
Name:	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; targeted mutation 1, Kazuo Sugamura
MGI ID:	MGI:2388123
Synonyms:	STAM1-/-
Gene:	Stam  Location: Chr2:14078910-14153296 bp, + strand  Genetic Position: Chr2, 10.36 cM, cytoband A2-B
Alliance:	Stamtm1Sug page

Germline Transmission:	Earliest citation of germline transmission: J:69504
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 3 and 4 encoding amino acids 44-99 with a neomycin resistance cassette. RT-PCR analysis of splenocyte RNA from homozygous mutant animals detected a mutant transcript with a frameshift and nonsense codon in exon 5. Western blot analysis of neocortex lysates and immunoprecipitation immunoblot of activated T cells from homozygous mutant animals did not detect a protein product. (J:69504)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stam Mutation:	43 strains or lines available

Original:	J:69504 Yamada M, et al., Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1. Mol Cell Biol. 2001 Jun;21(11):3807-19
All:	2 reference(s)