Tg(GAS)1Tcw
Transgene Detail
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| Symbol: |
Tg(GAS)1Tcw |
| Name: |
transgene insertion 1, Timothy C Wang |
| MGI ID: |
MGI:2384534 |
| Synonyms: |
MTI/G-GLY |
| Transgene: |
Tg(GAS)1Tcw Location: unknown
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| Alliance: |
Tg(GAS)1Tcw page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(GAS)1Tcw expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
GAST (2520) |
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Mutation details: The human gastrin gene engineered with a stop codon after glycine 72 and under the control of the mouse metallothionein promoter was used as the transgene. The transgene was verified by Southern blot analysis using a human gastrin exon 2 probe. Northern blot analysis detected transgene expression in kidney, liver, colon, stomach, and pancreas of transgenic animals using the exon 2 probe. RT-PCR analysis confirmed the expression of transcripts truncated after codon 72 in the colon of transgenic animals.
(J:54869)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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J:87479 specifies the use of transgenic line 7483.
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| Original: |
J:54869 Koh TJ, et al., Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest. 1999 Apr;103(8):1119-26 |
| All: |
8 reference(s) |
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Analysis Tools
