Tg(Fabpl-RAC1-Q61L)1Jig
Transgene Detail
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| Symbol: |
Tg(Fabpl-RAC1-Q61L)1Jig |
| Name: |
transgene insertion 1, Jeffrey I Gordon |
| MGI ID: |
MGI:2383955 |
| Synonyms: |
Rac1Leu61 |
| Transgene: |
Tg(Fabpl-RAC1-Q61L)1Jig Location: unknown
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| Alliance: |
Tg(Fabpl-RAC1-Q61L)1Jig page
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| Mouse Generated: |
Earliest citation of chimera generation:
J:62539
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| Parent Cell Line: |
D3 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Fabpl-RAC1-Q61L)1Jig expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
RAC1 (5879) |
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Transgene codes for a protein with a glutamine to leucine mutation. |
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Mutation details: A human RAC1 gene carrying a constitutive glutamine to leucine mutation at amino acid 61 was used for the transgene. Nucleotides -596 to +21 from Fabpl were used to drive expression of the transgene in intestinal epithelium. Western blot analysis confirmed the expression of the transgene in the small intestines of E18.5 chimeric embryos.
(J:62539)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Chimeric animals generated from the transgene died within a day after birth.
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| Original: |
J:62539 Stappenbeck TS, et al., Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestine. Development. 2000 Jun;127(12):2629-42 |
| All: |
1 reference(s) |
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Analysis Tools
