About   Help   FAQ
Tg(Col1a1-Bmpr1b)2Dic
Transgene Detail
Summary
Symbol: Tg(Col1a1-Bmpr1b)2Dic
Name: transgene insertion 2, Di Chen
MGI ID: MGI:2182337
Synonyms: tg(Col-2.3)
Transgene: Tg(Col1a1-Bmpr1b)2Dic  Location: unknown  
Alliance: Tg(Col1a1-Bmpr1b)2Dic page
Transgene
origin
Strain of Origin:  (C57BL/6 x BALB/c)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Col1a1-Bmpr1b)2Dic expresses 1 gene
 
Mutation details: A truncated Bmpr1b cDNA deleted for the kinase domain, and under the control of basal/enhancer sequences of the type 1 collagen promoter, was used to direct transgene expression in bone tissues. (J:77102)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Expression of truncated protein in bone tissues of transgenic animals was verified by RT-PCR and Western blot analysis. Homozygous transgenic mice exhibit a 22% decrease in body weight and 8-13% decrease in bone mineral density (BMD).
References
Original:  J:77102 Zhao M, et al., Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol. 2002 Jun 10;157(6):1049-60
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory