Tg(Col1a1-Bmpr1b)1Dic
Transgene Detail
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| Symbol: |
Tg(Col1a1-Bmpr1b)1Dic |
| Name: |
transgene insertion 1, Di Chen |
| MGI ID: |
MGI:2182336 |
| Synonyms: |
tg(Col-0.7) |
| Transgene: |
Tg(Col1a1-Bmpr1b)1Dic Location: unknown
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| Alliance: |
Tg(Col1a1-Bmpr1b)1Dic page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Col1a1-Bmpr1b)1Dic expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Bmpr1b (MGI:107191) |
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Mutation details: A truncated Bmpr1b cDNA deleted for the kinase domain was placed under the control of 0.7 kb of enhancer/basal promoter sequences from Col1a1 to drive transgene expression in bone tissues.
(J:77102)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Expression of truncated protein in bone tissues of transgenic animals was verified by RT-PCR and Western blot analysis. Homozygous transgenic mice exhibit a 12% decrease in body weight and 5-9% decrease in bone mineral density (BMD).
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| Original: |
J:77102 Zhao M, et al., Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol. 2002 Jun 10;157(6):1049-60 |
| All: |
1 reference(s) |
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