Tg(Ins1-BCL2L1)1Ksp
Transgene Detail
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| Symbol: |
Tg(Ins1-BCL2L1)1Ksp |
| Name: |
transgene insertion 1, Kenneth S Polonsky |
| MGI ID: |
MGI:2384544 |
| Synonyms: |
Fd 1 Bcl-xL |
| Transgene: |
Tg(Ins1-BCL2L1)1Ksp Location: unknown
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| Alliance: |
Tg(Ins1-BCL2L1)1Ksp page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Ins1-BCL2L1)1Ksp expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
BCL2L1 (598) |
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Mutation details: 0.82 kb of human BCL2L1 cDNA preceded by 0.5 kb of rat insulin 1 promoter sequences was used for the transgene. Specific expression of the transgene in beta-cells of the pancreas was confirmed by immunohistochemical analysis. Protein staining was detected in beta-cells of transgenic animals, but not in non-beta-cells, liver, exocrine tissue, small intestine, or lymph nodes. Western blot analysis showed expression of the human protein was 2- to 3-fold that of endogenous protein.
(J:78000)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:78000 Zhou YP, et al., Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51 |
| All: |
2 reference(s) |
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Analysis Tools
