Tg(BLG-Mdm2)1Caf
Transgene Detail
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| Symbol: |
Tg(BLG-Mdm2)1Caf |
| Name: |
transgene insertion 1, Cathy A Finlay |
| MGI ID: |
MGI:2386369 |
| Synonyms: |
BLGMDM2, TG3640 |
| Transgene: |
Tg(BLG-Mdm2)1Caf Location: unknown
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| Alliance: |
Tg(BLG-Mdm2)1Caf page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(BLG-Mdm2)1Caf expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Mdm2 (MGI:96952) |
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Mutation details: A full-length Mdm2 coding sequence (including introns 7 and 8) fused to the bovine beta-lactoglobulin (BLG) promoter, active in mammary glands, was used as the transgene. RNase protection assay of total RNA from mid-lactation mammary glands confirmed expression of the transgene intransgenic animals and detected both spliced and unspliced forms. Overexpression of the transgene was estimated to be 10-30 times that of the endogenous gene.
(J:72124)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:72124 Lundgren K, et al., Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 1997 Mar 15;11(6):714-25 |
| All: |
2 reference(s) |
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Analysis Tools
