Tg(Alb1-NR1I2)2Rev
Transgene Detail
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| Symbol: |
Tg(Alb1-NR1I2)2Rev |
| Name: |
transgene insertion 2, Ronald M Evans |
| MGI ID: |
MGI:2386095 |
| Synonyms: |
Alb-VP-PXR, Alb-VPSXR, VP-hPXR |
| Transgene: |
Tg(Alb1-NR1I2)2Rev Location: unknown
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| Alliance: |
Tg(Alb1-NR1I2)2Rev page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Alb1-NR1I2)2Rev expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
NR1I2 (8856) |
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Mutation details: An activated form of human NR1I2 cDNA fused a mouse liver-specific albumin promoter was used as the transgene. A sequence from the herpes simplex virus VP16 activation domain at the amino terminus of NR1I2 confers activated status to the human protein. Expression of the human transgene was verified by Northern blot analysis of liver tissue from transgenic animals.
(J:63639)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:63639 Xie W, et al., Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature. 2000 Jul 27;406(6794):435-9 |
| All: |
8 reference(s) |
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Analysis Tools
