Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnc2tm1Rudy
Name:	potassium voltage gated channel, Shaw-related subfamily, member 2; targeted mutation 1, Bernardo Rudy
MGI ID:	MGI:2387957
Synonyms:	Kv3.2 -
Gene:	Kcnc2  Location: Chr10:112107026-112302929 bp, + strand  Genetic Position: Chr10, 60.3 cM
Alliance:	Kcnc2tm1Rudy page

Germline Transmission:	Earliest citation of germline transmission: J:66730
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3' portion of exon 1, encoding the tetramerization domain (T domain) involved in oligomerization of potassium voltage gated channel subunits, was replaced by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice. (J:66730)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnc2 Mutation:	30 strains or lines available

Original:	J:66730 Lau D, et al., Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15;20(24):9071-85
All:	7 reference(s)