Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf4tm1Mak
Name:	interferon regulatory factor 4; targeted mutation 1, Tak Mak
MGI ID:	MGI:2387941
Synonyms:	IRF-4-, IRF4-
Gene:	Irf4  Location: Chr13:30933209-30950959 bp, + strand  Genetic Position: Chr13, 13.28 cM, cytoband A3.3
Alliance:	Irf4tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:42683
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of concanavalin A activated lymph nodes obtained from homozygous mutant mice. (J:42683)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Irf4 Mutation:	27 strains or lines available

Original:	J:42683 Mittrucker HW, et al., Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science. 1997 Jan 24;275(5299):540-3
All:	79 reference(s)