Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Htr1atm1Toth
Name:	5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Miklos Toth
MGI ID:	MGI:2387408
Synonyms:	5-HT(1A)-KO, 5-HT1A KO
Gene:	Htr1a  Location: Chr13:105580147-105584630 bp, + strand  Genetic Position: Chr13, 56.92 cM
Alliance:	Htr1atm1Toth page

Germline Transmission:	Earliest citation of germline transmission: J:49752
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted the start codon and 123 bp of coding sequence. Autoradiograhy analysis showed an absence of binding in coronal sections from homozygous mutant mice. (J:49752)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr1a Mutation:	26 strains or lines available

Original:	J:49752 Parks CL, et al., Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10734-9
All:	15 reference(s)