Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dcttm1(cre)Bee
Name:	dopachrome tautomerase; targeted mutation 1, Friedrich Beermann
MGI ID:	MGI:2387116
Synonyms:	Dct-, DctCre, Dct - KO
Gene:	Dct  Location: Chr14:118250202-118289656 bp, - strand  Genetic Position: Chr14, 61.6 cM
Alliance:	Dcttm1(cre)Bee page

Germline Transmission:	Earliest citation of germline transmission: J:79094
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Dcttm1(cre)Bee expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Dct (MGI:102563)   Mutation details: Exon 1, which is the first coding exon, was replaced with a cassette containing cre and neo. RT-PCR indicated an absence of normal transcript in homozygous mice. Normal protein was undetected by Western blot analysis of skin extracts and by immunohistochemical analysis of embryonic retinal pigment epithelium. (J:89896) Inheritance:    Recessive

Activity:	Tissue activity of this recombinase allele
Driver:	Dct (mouse) Summary of all recombinase alleles driven by Dct. Comparative matrix view of recombinase activities Alliance mouse Dct gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dct Mutation:	35 strains or lines available

Original:	J:79094 Guyonneau L, et al., Expression of cre recombinase in pigment cells. Pigment Cell Res. 2002 Aug;15(4):305-9
All:	13 reference(s)