Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ror2tm1Gdy
Name:	receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, George D Yancopoulos
MGI ID:	MGI:2386954
Synonyms:	Ror2-, Ror2TMlacZ
Gene:	Ror2  Location: Chr13:53263353-53440160 bp, - strand  Genetic Position: Chr13, 27.68 cM, cytoband B3
Alliance:	Ror2tm1Gdy page

Germline Transmission:	Earliest citation of germline transmission: J:60754
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the thymidine kinase-like domain with a lacZ-neo cassette resulting in the fusion of the ecto- and transmembrane-domains with lacZ. Beta-gal staining of mutant embryo sections and in situ hybridization analysis confirmed expression of the fusion product is similar to that of the endogenous protein. (J:60754)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	21 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror2 Mutation:	123 strains or lines available

Original:	J:60754 DeChiara TM, et al., Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet. 2000 Mar;24(3):271-4
All:	6 reference(s)