Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Chek2tm1Mak
Name:	checkpoint kinase 2; targeted mutation 1, Tak Mak
MGI ID:	MGI:2386905
Synonyms:	Chk2-
Gene:	Chek2  Location: Chr5:110987845-111022011 bp, + strand  Genetic Position: Chr5, 53.73 cM, cytoband F
Alliance:	Chek2tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:60946
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 8 through 11 were replaced with a neomycin selection cassette inserted via homologous recombination. Protein was undetected in homozygous mutant mice via Western blot analysis of various tissues. (J:60946, J:78491)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

List all tumor models in MMHCdb carrying Chek2tm1Mak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chek2 Mutation:	53 strains or lines available

Original:	J:60946 Hirao A, et al., DNA damage-induced activation of p53 by the checkpoint kinase Chk2 [see comments]. Science. 2000 Mar 10;287(5459):1824-7
All:	22 reference(s)