Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gckrtm1Jfg
Name:	glucokinase regulatory protein; targeted mutation 1, Joseph F Grippo
MGI ID:	MGI:2386670
Synonyms:	GKRP(-)
Gene:	Gckr  Location: Chr5:31454787-31484658 bp, + strand  Genetic Position: Chr5, 17.27 cM
Alliance:	Gckrtm1Jfg page

Germline Transmission:	Earliest citation of germline transmission: J:61183
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: Exons 4 and 5 were replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis. Western blot and immunhistochemical analyses verified the absence of protein. (J:61183)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gckr Mutation:	42 strains or lines available

Original:	J:61183 Grimsby J, et al., Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem. 2000 Mar 17;275(11):7826-31
All:	1 reference(s)