Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Npr1tm1Kuhn
Name:	natriuretic peptide receptor 1; targeted mutation 1, Michaela Kuhn
MGI ID:	MGI:2386604
Synonyms:	floxed GC-A, GC-A3lox
Gene:	Npr1  Location: Chr3:90357898-90373173 bp, - strand  Genetic Position: Chr3, 39.23 cM
Alliance:	Npr1tm1Kuhn page

Germline Transmission:	Earliest citation of germline transmission: J:76460
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 1, which contains the translational start codon, was flanked by an upstream floxed neo cassette and a downstream single loxP site. Quantitative RT-PCR of RNA obtained from aorta and pulmonary artery tissue showed normal levels of transcript in homozygous mutant mice. (J:76460)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:	60 strains or lines available

Original:	J:76460 Holtwick R, et al., Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7142-7
All:	22 reference(s)