Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slpitm1Smw
Name:	secretory leukocyte peptidase inhibitor; targeted mutation 1, Sharon M Wahl
MGI ID:	MGI:2386293
Gene:	Slpi  Location: Chr2:164195990-164231015 bp, - strand  Genetic Position: Chr2, 85.16 cM, cytoband H
Alliance:	Slpitm1Smw page

Germline Transmission:	Earliest citation of germline transmission: J:65241
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence extending from nucleotide -849 through nucleotide 46 was replaced with a neomycin selection cassette. Deletion of this region eliminated regulatory elements, sequence encoding the first 16 amino acids, and introduced a frameshift mutation. Northern blot analysis confirmed the absence of transcript in homozygous mutant mice. (J:65241)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slpi Mutation:	17 strains or lines available

Original:	J:65241 Ashcroft GS, et al., Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med. 2000 Oct;6(10):1147-53
All:	10 reference(s)