Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Plcg2tm1Jni Name: phospholipase C, gamma 2; targeted mutation 1, James N Ihle MGI ID: MGI:2386100 Synonyms: PLCgamma2- Gene: Plcg2  Location: Chr8:118225030-118361881 bp, + strand  Genetic Position: Chr8, 64.26 cM Alliance: Plcg2tm1Jni page

Plcg2tm1Jni/Plcg2tm1Jni mice are protected from mBSA-induced arthritis Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:63679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.8 kb region of the gene containing exon 2 was replaced with a neomycin resistance gene via homologous recombination. Spleen extracts from homozygous mutant animals did not contain protein product as determined by immunoprecipitation and Western blot analysis using antibodies directed against the C-terminus of the protein. (J:63679)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Plcg2 Mutation:	74 strains or lines available

Original:	J:63679 Wang D, et al., Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity. 2000 Jul;13(1):25-35
All:	44 reference(s)