Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Nrastm1Rak
Name:	neuroblastoma ras oncogene; targeted mutation 1, Raju Kucherlapati
MGI ID:	MGI:2385944
Synonyms:	N-ras-
Gene:	Nras  Location: Chr3:102965643-102975230 bp, + strand  Genetic Position: Chr3, 45.25 cM
Alliance:	Nrastm1Rak page

Germline Transmission:	Earliest citation of germline transmission: J:23318
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 2.2 kb of sequence from the 3' portion of exon 2 were replaced with a neomycin selection cassette via homologous recombination. The deleted sequence encoded two thirds of the carboxy terminal amino acids. Protein was undetected by Western blot analysis of extracts obtained from the lungs of homozygous mutant mice. (J:23318)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

15 assay results

List all tumor models in MMHCdb carrying Nrastm1Rak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nras Mutation:	44 strains or lines available

Original:	J:23318 Umanoff H, et al., The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1709-13
All:	20 reference(s)