Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Rxratm1Krc
Name:	retinoid X receptor alpha; targeted mutation 1, Kenneth R Chien
MGI ID:	MGI:2385918
Synonyms:	RXRalphafl, RXRalphaflox, RXRalphafloxed
Gene:	Rxra  Location: Chr2:27566452-27652969 bp, + strand  Genetic Position: Chr2, 19.38 cM
Alliance:	Rxratm1Krc page

Germline Transmission:	Earliest citation of germline transmission: J:48085
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was introduced into intron 3 and a floxed PGK-neo-tk cassette was introduced into intron 4 via homologous recombination. The PGK-neo-tk cassette was subsequently removed in correctly targeted cells by the transient expression of cre recombinase, leaving behind loxP sites flanking exon 4. (J:48085)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Rxratm1Krc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:	30 strains or lines available

Original:	J:48085 Chen J, et al., Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development. 1998 May;125(10):1943-9
All:	29 reference(s)