Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dmrt1tm1.1Zark
Name:	doublesex and mab-3 related transcription factor 1; targeted mutation 1.1, David Zarkower
MGI ID:	MGI:2385912
Synonyms:	Dmrt1-
Gene:	Dmrt1  Location: Chr19:25483070-25581692 bp, + strand  Genetic Position: Chr19, 20.45 cM, cytoband C2-C3
Alliance:	Dmrt1tm1.1Zark page

Germline Transmission:	Earliest citation of germline transmission: J:65541
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed sequences of Dmrt1tm1Zark were deleted by mating mice carrying this allele to the cre-expressing TgN(ACTB-cre)2Mrt line. The cre-mediated recombination event removes the promoter, the major translation initiation codon, exon 1 (which contains the zinc-finger-like DM domain), the neomycin resistance gene, and part of intron 1. Homozygous mutant animals did not express protein product as demonstrated by immunohistochemical analysis of testes sections. (J:65541)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmrt1 Mutation:	48 strains or lines available

Original:	J:65541 Raymond CS, et al., Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev. 2000 Oct 15;14(20):2587-95
All:	8 reference(s)