Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pla2g4atm1Tksh
Name:	phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1, Takao Shimizu
MGI ID:	MGI:2385582
Synonyms:	cpla2-, cPLA2alpha, cPLA2 GIVA, IVA PLA2-
Gene:	Pla2g4a  Location: Chr1:149705369-149837041 bp, - strand  Genetic Position: Chr1, 63.51 cM
Alliance:	Pla2g4atm1Tksh page

Germline Transmission:	Earliest citation of germline transmission: J:39254
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of part of the exon encoding the lipase consensus motif and serine 228, a residue required for enzymatic activity. Absence of gene expression in the spleen of homozygous animals was verified by Northern blot and Western blot analyses. (J:39254)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pla2g4a Mutation:	61 strains or lines available

Original:	J:39254 Uozumi N, et al., Role of cytosolic phospholipase A2 in allergic response and parturition. Nature. 1997 Dec 11;390(6660):618-22
All:	38 reference(s)