Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hfetm2Nca
Name:	homeostatic iron regulator; targeted mutation 2, Nancy C Andrews
MGI ID:	MGI:2385353
Synonyms:	Hfe-
Gene:	Hfe  Location: Chr13:23886017-23894837 bp, - strand  Genetic Position: Chr13, 9.88 cM, cytoband A2-A4
Alliance:	Hfetm2Nca page

Germline Transmission:	Earliest citation of germline transmission: J:78536
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A LoxP site flanked neomycin resistance gene cassette replaced a segment of genomic sequence starting in exon 3 and ending in intron 4. (J:78536)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hfe Mutation:	34 strains or lines available

Original:	J:78536 Levy JE, et al., The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood. 1999 Jul 1;94(1):9-11
All:	46 reference(s)