Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tgfbr2tm1Hlm
Name:	transforming growth factor, beta receptor II; targeted mutation 1, Harold L Moses
MGI ID:	MGI:2384511
Gene:	Tgfbr2  Location: Chr9:115916763-116004431 bp, - strand  Genetic Position: Chr9, 68.39 cM
Alliance:	Tgfbr2tm1Hlm page

Germline Transmission:	Earliest citation of germline transmission: J:75073
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A construct, in which exon 2 was surrounded by a loxP site in intron 1 and a floxed neo gene in intron 2, was incorporated at the endogenous locus via homologous recombination. (J:75073)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tgfbr2tm1Hlm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:	39 strains or lines available

Original:	J:75073 Chytil A, et al., Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb;32(2):73-5
All:	38 reference(s)