Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-DMatm1Doi
Name:	histocompatibility 2, class II, locus DMa; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID:	MGI:2384509
Synonyms:	DM0, H2-DMatm1Dim, H-2Mo, Ma-, Mo
Gene:	H2-DMa  Location: Chr17:34338667-34358075 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-DMatm1Doi page

Germline Transmission:	Earliest citation of germline transmission: J:31624
Parent Cell Line:	P1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encompassing all of exon 1 and a portion of exon 2 was replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via RT-PCR analysis of total spleen RNA. (J:31624)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-DMa Mutation:	27 strains or lines available

Original:	J:31624 Miyazaki T, et al., Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 1996 Feb 23;84(4):531-41
All:	10 reference(s)