Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pitx2tm1Rsd
Name:	paired-like homeodomain transcription factor 2; targeted mutation 1, Michael G Rosenfeld
MGI ID:	MGI:2384494
Synonyms:	Pitx2-, Pitx2LacZ
Gene:	Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance:	Pitx2tm1Rsd page

Germline Transmission:	Earliest citation of germline transmission: J:57673
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the entire homeodomain and C-terminus with an in-frame lacZ-neo cassette via homologous recombination. Southern blot analysis identified homozygous mutant embryos up to E15. X-gal staining of mutant embryos demonstrated the expression pattern of the lacZ targeted insert is similar to that of endogenous protein. (J:57673)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	342 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:	38 strains or lines available

Original:	J:57673 Lin CR, et al., Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature. 1999 Sep 16;401(6750):279-82
All:	10 reference(s)