Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rbms1tm1Hiro
Name:	RNA binding motif, single stranded interacting protein 1; targeted mutation 1, Hiroyoshi Ariga
MGI ID:	MGI:2384095
Synonyms:	Mssp-
Gene:	Rbms1  Location: Chr2:60580537-60793536 bp, - strand  Genetic Position: Chr2, 34.95 cM, cytoband C3
Alliance:	Rbms1tm1Hiro page

Germline Transmission:	Earliest citation of germline transmission: J:77893
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis. Western blot using polyclonal antibodies directed against amino acids 343-370 did not detect protein product in homozygous mutants. (J:77893)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rbms1 Mutation:	46 strains or lines available

Original:	J:77893 Fujimoto M, et al., Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice. Genes Cells. 2001 Dec;6(12):1067-75
All:	2 reference(s)