Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gfra3tm1Jmi
Name:	glial cell line derived neurotrophic factor family receptor alpha 3; targeted mutation 1, Jeffrey Milbrandt
MGI ID:	MGI:2183558
Synonyms:	GFRalpha3tlacZ
Gene:	Gfra3  Location: Chr18:34822951-34853440 bp, - strand  Genetic Position: Chr18, 18.69 cM
Alliance:	Gfra3tm1Jmi page

Germline Transmission:	Earliest citation of germline transmission: J:78008
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The endogenous locus was disrupted by the insertion of a tau-lacZ cassette at the start codon by homologous recombination. A floxed neo cassette that was included in the targeting vector was excised via in vivo cre mediated recombination, leaving a single loxP site immediately downstream of the tau-lacZ sequence. Normal transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:78008)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra3 Mutation:	31 strains or lines available

Original:	J:78008 Honma Y, et al., Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron. 2002 Jul 18;35(2):267-82
All:	3 reference(s)