Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnj2tm1Swz
Name:	potassium inwardly-rectifying channel, subfamily J, member 2; targeted mutation 1, Thomas L Schwarz
MGI ID:	MGI:2183430
Synonyms:	Kir2.1-
Gene:	Kcnj2  Location: Chr11:110956990-110967647 bp, + strand  Genetic Position: Chr11, 75.23 cM
Alliance:	Kcnj2tm1Swz page

Germline Transmission:	Earliest citation of germline transmission: J:78077
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire open reading frame of the endogenous gene was replaced with a neomycin selection cassette. (J:78077)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj2 Mutation:	28 strains or lines available

Original:	J:78077 Zaritsky JJ, et al., Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Circ Res. 2000 Jul 21;87(2):160-6
All:	6 reference(s)