Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Olig2tm1(cre/Esr1*)Htak
Name:	oligodendrocyte transcription factor 2; targeted mutation 1, Hirohide Takebayashi
MGI ID:	MGI:2183410
Synonyms:	Olig2-, Olig2-CreER, Olig2KICreER, Olig2tm1(cre/Esr1)Htak, Olig2tm1(cre/Esr1)Yin
Gene:	Olig2  Location: Chr16:91022345-91025565 bp, + strand  Genetic Position: Chr16, 52.6 cM
Alliance:	Olig2tm1(cre/Esr1*)Htak page

Germline Transmission:	Earliest citation of germline transmission: J:77821
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Olig2tm1(cre/Esr1*)Htak expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Olig2 (MGI:1355331)   Mutation details: The portion of exon 2 encoding the basic helix-loop-helix domain was replaced with a cassette containing neo and tamoxifen-inducible cre genes. The expression of the inducible cre gene was driven by the endogenous promoter. (J:77821)

Activity:	Tissue activity of this recombinase allele
Driver:	Olig2 (mouse) Summary of all recombinase alleles driven by Olig2. Alliance mouse Olig2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Olig2 Mutation:	46 strains or lines available

Original:	J:77821 Takebayashi H, et al., The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol. 2002 Jul 9;12(13):1157-63
All:	30 reference(s)