Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Neurog1tm1And
Name:	neurogenin 1; targeted mutation 1, David J Anderson
MGI ID:	MGI:2183171
Synonyms:	ngn1-, Ngn1GFP
Gene:	Neurog1  Location: Chr13:56398291-56399976 bp, - strand  Genetic Position: Chr13, 30.06 cM
Alliance:	Neurog1tm1And page

Germline Transmission:	Earliest citation of germline transmission: J:46668
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon containing the entire coding region of the gene was replaced with a GFP-PGK-neo cassette via homologous recombination. In situ hybridization analysis of E10.5 embryos demonstrated the absence of gene expression in homozygous mutants. GFP transcripts were detected in mutant animals in a pattern indistinguishable from the endogenous mRNA but no fluorescent signal could be detected. (J:46668)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	207 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neurog1 Mutation:	19 strains or lines available

Original:	J:46668 Ma Q, et al., neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron. 1998 Mar;20(3):469-82
All:	46 reference(s)