Tsc1tm1Hin
Targeted Allele Detail
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| Symbol: |
Tsc1tm1Hin |
| Name: |
TSC complex subunit 1; targeted mutation 1, Okio Hino |
| MGI ID: |
MGI:2183146 |
| Synonyms: |
Tsc1- |
| Gene: |
Tsc1 Location: Chr2:28531240-28581179 bp, + strand Genetic Position: Chr2, 19.38 cM, cytoband B-C1.1
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| Alliance: |
Tsc1tm1Hin page
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Analysis of Tsc1tm1Hin/Tsc1tm1Hin embryos
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:70463
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 6-8, a region of the gene conserved between mammals and fly and thought to be functionally important, were replaced with an IRES-EGFP-pA-neo cassette via homologous recombination. Splicing of exons 5-9 should result in a frameshift. Northern blot of homozygous mutant embryos detected a mutant transcript deleted for approximately 8 kb of mRNA.
(J:70463)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tsc1 Mutation: |
69 strains or lines available
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| Original: |
J:70463 Kobayashi T, et al., A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8762-7 |
| All: |
4 reference(s) |
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Analysis Tools
