Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mtf1tm1Wsc
Name:	metal response element binding transcription factor 1; targeted mutation 1, Walter Schaffner
MGI ID:	MGI:2182939
Synonyms:	MTF-1-
Gene:	Mtf1  Location: Chr4:124696342-124743593 bp, + strand  Genetic Position: Chr4, 57.91 cM, cytoband D1
Alliance:	Mtf1tm1Wsc page

Germline Transmission:	Earliest citation of germline transmission: J:48216
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced sequences encoding the first two and a portion of the third zinc-finger domain. RT-PCR analysis of RNA from mutant embryos revealed the presence of an amino-terminal fragment, truncating 39 base pairs downstream of the 5' insertion point. The truncated transcript lacks sequence encoding 3 zinc-finger domains and the acidic, proline-rich, and serine/threonine-rich regions. (J:19100, J:48216)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtf1 Mutation:	38 strains or lines available

Original:	J:48216 Gunes C, et al., Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 1998 May 15;17(10):2846-54
All:	6 reference(s)