Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fkbp1btm1Syf
Name:	FK506 binding protein 1b; targeted mutation 1, Sidney Fleischer
MGI ID:	MGI:2182644
Synonyms:	FKBP12.6-
Gene:	Fkbp1b  Location: Chr12:4883174-4891591 bp, - strand  Genetic Position: Chr12, 2.09 cM
Alliance:	Fkbp1btm1Syf page

Germline Transmission:	Earliest citation of germline transmission: J:75646
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3, which encodes binding sites for Ryr2, FK506, and calcineurin, was replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in hearts from homozygous mutant animals as demonstrated by RT-PCR analysis. (J:75646)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp1b Mutation:	14 strains or lines available

Original:	J:75646 Xin HB, et al., Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature. 2002 Mar 21;416(6878):334-8
All:	15 reference(s)