Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbpl1tm1Saco
Name:	TATA box binding protein-like 1; targeted mutation 1, Paolo Sassone-Corsi
MGI ID:	MGI:2182539
Synonyms:	TLF-
Gene:	Tbpl1  Location: Chr10:22579778-22607837 bp, - strand  Genetic Position: Chr10, 10.25 cM, cytoband A3
Alliance:	Tbpl1tm1Saco page

Germline Transmission:	Earliest citation of germline transmission: J:68789
Parent Cell Line:	H1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by insertion of a loxP-flanked PGK-hygro cassette into exon 4 via homologous recombination. The gene targeting event results in truncation of the protein at amino acid 88 and elimination of the DNA binding surface. Gene expression is strongly decreased in brain and testes of homozygous mutant animals as determined by Northern blot. Protein product was not detected in testes of homozygous mutants as determined by Western blot. (J:68789)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbpl1 Mutation:	10 strains or lines available

Original:	J:68789 Martianov I, et al., Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene. Mol Cell. 2001 Mar;7(3):509-15
All:	3 reference(s)