Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sp3tm1Sus
Name:	trans-acting transcription factor 3; targeted mutation 1, Guntram Suske
MGI ID:	MGI:2182438
Synonyms:	Sp3-
Gene:	Sp3  Location: Chr2:72766774-72810790 bp, - strand  Genetic Position: Chr2, 43.35 cM, cytoband C3
Alliance:	Sp3tm1Sus page

Germline Transmission:	Earliest citation of germline transmission: J:60658
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2, which encodes the glutamine-rich activation domain, was replaced with a cassette containing an IRES-lacZ-neo fusion gene, adjoined to a splice acceptor site. The three isoforms produced from the endogenous allele were undetected in homozygous mutant mice by Western blot analysis of nuclear extracts. (J:60658)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	49 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sp3 Mutation:	64 strains or lines available

Original:	J:60658 Bouwman P, et al., Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000 Feb 15;19(4):655-61
All:	10 reference(s)